Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages
of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently …

Despite the introduction of numerous biologic agents for the treatment of rheumatoid arthritis
(RA) and other forms of inflammatory arthritis, low-dose methotrexate therapy remains the …

Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and
its antiatherogenic properties support cardiovascular homeostasis. Diminished NO …

Methotrexate (MTX) is used as an anchor disease-modifying anti-rheumatic drugs
(DMARDs) in treating rheumatoid arthritis (RA) because of its potent efficacy and tolerability …

Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

The B-vitamins comprise a group of eight water soluble vitamins that perform essential,
closely inter-related roles in cellular functioning, acting as co-enzymes in a vast array of …

Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

Endothelial cells situated at the interface between blood and the vessel wall play a crucial
role in controlling vascular tone and homeostasis, particularly in determining the expression …

Reduced nitric oxide bioavailability contributes to endothelial dysfunction and hypertension.
The endothelial isoform of nitric oxide synthase (eNOS) is responsible for the production of …