Abstract N 6-methyladenosine (m6A) is a modified base that has long been known to be
present in non-coding RNAs, ribosomal RNA, polyadenylated RNA and at least one …

GTP-binding (G) proteins constitute a class of P-loop (phosphate-binding loop) proteins that
work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The …

After termination, eukaryotic 80S ribosomes remain associated with mRNA, P-site
deacylated tRNA, and release factor eRF1 and must be recycled by dissociating these …

Eukaryotic ribosomes are significantly larger and more complex than their prokaryotic
counterparts. This parallels the increased complexity of the associated cellular machinery …

Expansion segments (ESs) are enigmatic insertions within the eukaryotic ribosome, the
longest of which resemble tentacle-like extensions that vary in length and sequence across …

Highlights•Collided ribosomes form a unique disomal interface and are a hallmark of
slow/stalled translation.•Ribosome ubiquitination is triggered by ribosome collisions …

Protein synthesis is targeted by numerous, chemically distinct antibiotics that bind and inhibit
key functional centers of the ribosome. Using single-molecule imaging and X-ray …

All organisms have evolved mechanisms to manage the stalling of ribosomes upon
translation of aberrant mRNA. In eukaryotes, the large ribosomal subunit-associated quality …

We investigated the genetic basis for a global and uniform decrease in mitochondrial
translation in fibroblasts from patients in two unrelated pedigrees who developed Leigh …

Important regions of rRNA are rich in nucleotide modifications that can have strong effects
on ribosome biogenesis and translation efficiency. Here, we examine the influence of …