Development and characterization of NILK-2301, a novel CEACAM5xCD3 κλ bispecific antibody for immunotherapy of CEACAM5-expressing cancers
A Seckinger, S Majocchi, V Moine, L Nouveau… - Journal of Hematology & …, 2023 - Springer
Background T-cell retargeting to eliminate CEACAM5-expressing cancer cells via
CEACAM5xCD3 bispecific antibodies (BsAbs) showed limited clinical activity so far, mostly …
CEACAM5xCD3 bispecific antibodies (BsAbs) showed limited clinical activity so far, mostly …
Special issue “new developments in natural killer cells for immunotherapy”
Since their formal discovery in 1975, natural killer (NK) cells have always been proposed in
the literature as a potential treatment for cancer and viral infections. This recommendation …
the literature as a potential treatment for cancer and viral infections. This recommendation …
INTASYL self-delivering RNAi decreases TIGIT expression, enhancing NK cell cytotoxicity: a potential application to increase the efficacy of NK adoptive cell therapy …
M Maxwell, D Yan, B Rivest, A Boone, J Cardia… - Cancer Immunology …, 2024 - Springer
Natural killer (NK) cells are frontline defenders against cancer and are capable of
recognizing and eliminating tumor cells without prior sensitization or antigen presentation …
recognizing and eliminating tumor cells without prior sensitization or antigen presentation …
Euphohelioscopin A enhances NK cell antitumor immunity through GSDME-triggered pyroptosis
C Gong, H Mu, J Luo, R Zhang, D Hu… - Journal of Leukocyte …, 2024 - academic.oup.com
Immune evasion by cancer cells poses a significant challenge for natural killer cell–based
immunotherapy. Pyroptosis, a newly discovered form of programmed cell death, has shown …
immunotherapy. Pyroptosis, a newly discovered form of programmed cell death, has shown …
Immunogenomics and spatial proteomic mapping highlight distinct neuro-immune architectures in melanoma vs. non-melanoma-derived brain metastasis
A Mendoza-Valderrey, E Dettmann, D Hanes… - BJC Reports, 2024 - nature.com
Abstract Background Brain metastases (BrMs) are a devastating complication of solid
tumours. A better understanding of BrMs biology is needed to address their challenging …
tumours. A better understanding of BrMs biology is needed to address their challenging …
Cholesterol‐regulated cellular stiffness may enhance evasion of NK cell‐mediated cytotoxicity in gastric cancer stem cells
L Zhu, H Wang - FEBS Open bio, 2024 - Wiley Online Library
Gastric cancer has a high rate of recurrence, and as such, immunotherapy strategies are
being investigated as a potential therapeutic strategy. Although the involvement of immune …
being investigated as a potential therapeutic strategy. Although the involvement of immune …