Introduction Covalent drugs have been used for more than hundred years, but gathered
larger interest in the last two decades. There are currently over a 100 different electrophilic …

The key proteins involved in transcriptional regulation play convergent roles in cellular
homeostasis, and their dysfunction mediates aberrant gene expressions that underline the …

Compilation, curation, digitization, and exploration of the phytochemical space of Indian
medicinal plants can expedite ongoing efforts toward natural product and traditional …

Single-cell proteomics (SCP) has emerged as a powerful tool for detecting cellular
heterogeneity, offering unprecedented insights into biological mechanisms that are masked …

Fragment based drug discovery has long been used for the identification of new ligands and
interest in targeted covalent inhibitors has continued to grow in recent years, with high …

In recent years, the drug discovery paradigm has shifted toward compounds that covalently
modify disease-associated target proteins, because they tend to possess high potency …

Covalent drug discovery has undergone a resurgence over the past two decades and
reactive cysteine profiling has emerged in parallel as a platform for ligand discovery through …

As natural proteins generally do not bind targets in a covalent mode, the therapeutic
potential of covalent protein drugs remains largely unexplored. Recently, latent bioreactive …

The reactive functionalities of drugs that engage in covalent interactions with the
enzyme/receptor residue in either a reversible or an irreversible manner are …

The Kirsten rat sarcoma viral G12C (KRASG12C) protein is one of the most common
mutations in non-small-cell lung cancer (NSCLC). KRASG12C inhibitors are promising for …