Fish response to hypoxia stress: growth, physiological, and immunological biomarkers
Water quality encompasses the water physical, biological, and chemical parameters. It
generally affects the fish growth and welfare. Thus, the success of a commercial aquaculture …
generally affects the fish growth and welfare. Thus, the success of a commercial aquaculture …
Transcriptional regulation by hypoxia inducible factors
VL Dengler, MD Galbraith… - Critical reviews in …, 2014 - Taylor & Francis
The cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …
Hypoxia induces rapid changes to histone methylation and reprograms chromatin
M Batie, J Frost, M Frost, JW Wilson, P Schofield… - Science, 2019 - science.org
Oxygen is essential for the life of most multicellular organisms. Cells possess enzymes
called molecular dioxygenases that depend on oxygen for activity. A subclass of molecular …
called molecular dioxygenases that depend on oxygen for activity. A subclass of molecular …
iRegulon: from a gene list to a gene regulatory network using large motif and track collections
R Janky, A Verfaillie, H Imrichová… - PLoS computational …, 2014 - journals.plos.org
Identifying master regulators of biological processes and mapping their downstream gene
networks are key challenges in systems biology. We developed a computational method …
networks are key challenges in systems biology. We developed a computational method …
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
Although long non-coding RNAs (lncRNAs) predominately reside in the nucleus and exert
their functions in many biological processes, their potential involvement in cytoplasmic …
their functions in many biological processes, their potential involvement in cytoplasmic …
Fructose-1, 6-bisphosphatase opposes renal carcinoma progression
Clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, is
characterized by elevated glycogen levels and fat deposition. These consistent metabolic …
characterized by elevated glycogen levels and fat deposition. These consistent metabolic …
APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
S Lee, NA Devanney, LR Golden, CT Smith… - Cell reports, 2023 - cell.com
The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and
a heightened pro-inflammatory response: two findings that may be intrinsically linked …
a heightened pro-inflammatory response: two findings that may be intrinsically linked …
Hypoxia, hypoxia-inducible transcription factors, and renal cancer
Context Renal cancer is a common urologic malignancy, and therapeutic options for
metastatic disease are limited. Most clear cell renal cell carcinomas (ccRCC) are associated …
metastatic disease are limited. Most clear cell renal cell carcinomas (ccRCC) are associated …
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
J Schödel, S Oikonomopoulos… - Blood, The Journal …, 2011 - ashpublications.org
Hypoxia-inducible factor (HIF) regulates the major transcriptional cascade central to the
response of all mammalian cells to alterations in oxygen tension. Expression arrays indicate …
response of all mammalian cells to alterations in oxygen tension. Expression arrays indicate …
Transcriptional response to hypoxia: the role of HIF-1-associated co-regulators
The Hypoxia Inducible Factor 1 (HIF-1) plays a major role in the cellular response to hypoxia
by regulating the expression of many genes involved in adaptive processes that allow cell …
by regulating the expression of many genes involved in adaptive processes that allow cell …