Owing to the unique ability of antibodies that bind the membrane proximal region of the
extracellular domain to trigger conformational changes leading to affinity modulation and …

PECAM-1 (also known as CD31) is a cellular adhesion and signaling receptor comprising
six extracellular immunoglobulin (Ig)-like homology domains, a short transmembrane …

In mammals, specification of the three major germ layers occurs during gastrulation, when
cells ingressing through the primitive streak differentiate into the precursor cells of major …

Vascular endothelial growth factor (VEGF), which acts via members of a family of endothelial-
specific receptor tyrosine kinases, is the only factor that has been shown definitively to play a …

THE vascular endothelial growth factor (VEGF) and its high-affinity binding receptors, the
tyrosine kinases Flt-1 and Flk-1, are thought to be important for the development of …

Vascularization of organs generally occurs by remodelling of the preexisting vascular
system during their differentiation and growth to enable them to perform their specific …

Abstract TIE-1 and Tie-2 define a new class of receptor tyrosine kinases that are specifically
expressed in developing vascular endothelial cells. To study the functions of Tie-1 and Tie-2 …

The Notch gene family encodes large transmembrane receptors that are components of an
evolutionarily conserved intercellular signaling mechanism. To assess the role of the Notch4 …

Platelet endothelial cell adhesion molecule-1 (PECAM-1 or CD31) is a molecule expressed
on all cells within the vascular compartment, being expressed to different degrees on most …

Cardiac fibroblasts, myocytes, endothelial cells, and vascular smooth muscle cells are the
major cellular constituents of the heart. The aim of this study was to observe alterations in …