The tongue is a complex multifunctional organ that interacts and senses both interoceptively
and exteroceptively. Although it is easily visible to almost all of us, it is relatively …

The transmembrane E3 ligases RNF43 and ZNRF3 perform key tumour suppressor roles by
inducing endocytosis of members of the Frizzled (FZD) family, the primary receptors for …

Mammalian taste buds are highly regenerative and can restore themselves after normal
wear and tear of the lingual epithelium or following physical and chemical insults, including …

Experimental or traumatic nerve injury causes the degeneration of associated taste buds.
Unlike most sensory systems, the sectioned nerve and associated taste buds can then …

Objective To decipher the role of locally injected bone marrow mesenchymal stem cells (BM-
MSCs) in the tongue of hypothyroid rats. Design A total 24 male Wister rats were utilized and …

Taste buds, the neuroepithelial organs responsible for the detection of gustatory stimuli in
the oral cavity, arise from stem/progenitor cells among nearby basal keratinocytes. Using …

Many common chemotherapeutics produce disruptions in the sense of taste which can lead
to loss of appetite, nutritional imbalance, and reduced quality of life, especially if taste loss …

As evolutionarily conserved signals, roof plate-specific spondins (R-spondins; RSPOs) are a
family with four members (RSPO1–4) exerting distinctly different functions. RSPOs have five …

Taste buds undergo continuous cell turnover throughout life, and taste cell replenishment
relies strictly on innervation, a phenomenon first described almost 150 years ago. Recently …

The transmembrane E3 ligases RNF43 and ZNRF3 perform key tumour suppressor roles by
depleting members of the Frizzled (FZD) family, the primary receptors for WNTs, from the cell …