Pediatric low-grade glioma in the era of molecular diagnostics
Low grade gliomas are the most frequent brain tumors in children and encompass a
spectrum of histologic entities which are currently assigned World Health Organisation …
spectrum of histologic entities which are currently assigned World Health Organisation …
The current state of molecular testing in the treatment of patients with solid tumors, 2019
The world of molecular profiling has undergone revolutionary changes over the last few
years as knowledge, technology, and even standard clinical practice have evolved. Broad …
years as knowledge, technology, and even standard clinical practice have evolved. Broad …
[HTML][HTML] Dabrafenib plus Trametinib in Pediatric Glioma with BRAF V600 Mutations
Background Detection of the BRAF V600E mutation in pediatric low-grade glioma has been
associated with a lower response to standard chemotherapy. In previous trials, dabrafenib …
associated with a lower response to standard chemotherapy. In previous trials, dabrafenib …
Integrated molecular and clinical analysis of 1,000 pediatric low-grade gliomas
Pediatric low-grade gliomas (pLGG) are frequently driven by genetic alterations in the RAS-
mitogen-activated protein kinase (RAS/MAPK) pathway yet show unexplained variability in …
mitogen-activated protein kinase (RAS/MAPK) pathway yet show unexplained variability in …
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre …
J Fangusaro, A Onar-Thomas, TY Poussaint… - The lancet …, 2019 - thelancet.com
Background Paediatric low-grade glioma is the most common CNS tumour of childhood.
Although overall survival is good, disease often recurs. No single universally accepted …
Although overall survival is good, disease often recurs. No single universally accepted …
Efficacy and Safety of Trametinib Monotherapy or in Combination With Dabrafenib in Pediatric BRAF V600–Mutant Low-Grade Glioma
E Bouffet, B Geoerger, C Moertel… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE BRAF V600 mutations occur in many childhood cancers, including approximately
20% of low-grade gliomas (LGGs). Here, we describe a phase I/II study establishing …
20% of low-grade gliomas (LGGs). Here, we describe a phase I/II study establishing …
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas
AS Guerreiro Stucklin, S Ryall, K Fukuoka… - Nature …, 2019 - nature.com
Infant gliomas have paradoxical clinical behavior compared to those in children and adults:
low-grade tumors have a higher mortality rate, while high-grade tumors have a better …
low-grade tumors have a higher mortality rate, while high-grade tumors have a better …
BRAF Inhibition in BRAFV600-Mutant Gliomas: Results From the VE-BASKET Study
Purpose BRAF V600 mutations are frequently found in several glioma subtypes, including
pleomorphic xanthoastrocytoma (PXA) and ganglioglioma and much less commonly in …
pleomorphic xanthoastrocytoma (PXA) and ganglioglioma and much less commonly in …
Clinical applications of artificial intelligence and radiomics in neuro-oncology imaging
This article is a comprehensive review of the basic background, technique, and clinical
applications of artificial intelligence (AI) and radiomics in the field of neuro-oncology. A …
applications of artificial intelligence (AI) and radiomics in the field of neuro-oncology. A …
Efficacy and Safety of Dabrafenib in Pediatric Patients with BRAF V600 Mutation–Positive Relapsed or Refractory Low-Grade Glioma: Results from a Phase I/IIa Study
Purpose: Pediatric low-grade glioma (pLGG) is the most prevalent childhood brain tumor.
Patients with BRAF V600 mutation–positive pLGG may benefit from treatment with …
Patients with BRAF V600 mutation–positive pLGG may benefit from treatment with …