Thapsigargin—from traditional medicine to anticancer drug

A Jaskulska, AE Janecka, K Gach-Janczak - International journal of …, 2020 - mdpi.com
A sesquiterpene lactone, thapsigargin, is a phytochemical found in the roots and fruits of
Mediterranean plants from Thapsia L. species that have been used for centuries in folk …

The role of activated charcoal in plant tissue culture

TD Thomas - Biotechnology advances, 2008 - Elsevier
Activated charcoal has a very fine network of pores with large inner surface area on which
many substances can be adsorbed. Activated charcoal is often used in tissue culture to …

Thapsigargin—From Thapsia L. to Mipsagargin

TB Andersen, CQ López, T Manczak, K Martinez… - Molecules, 2015 - mdpi.com
The sesquiterpene lactone thapsigargin is found in the plant Thapsia garganica L., and is
one of the major constituents of the roots and fruits of this Mediterranean species. In 1978 …

Thapsigargin and its prodrug derivatives: exploring novel approaches for targeted cancer therapy through calcium signaling disruption

I Khurram, MU Khan, S Ibrahim, MU Ghani, I Amin… - Medical Oncology, 2025 - Springer
Thapsigargin, a sesquiterpene lactone derived from Thapsia garganica L., has
demonstrated mixed potential as an anticancer agent due to its potent ability to disrupt …

Callus induction and plant regeneration in Dorem ammoniacum D., an endangered medicinal plant

N Irvani, M Solouki, M Omidi, AR Zare… - Plant Cell, Tissue and …, 2010 - Springer
Abstract Dorema ammoniacum D. Don.(Apiaceae), a native medicinal plant in Iran, is
classified as a vulnerable species. Root, hypocotyl, and cotyledon segments were cultured …

Antioxidant enzyme activities, malondialdehyde, and total phenolic content of PEG-induced hyperhydric leaves in sugar beet tissue culture

A Sen, S Alikamanoglu - In Vitro Cellular & Developmental Biology-Plant, 2013 - Springer
Hyperhydricity is a physiological abnormality that frequently affects shoots that are
vegetatively propagated in vitro. In this study, sugar beet (Beta vulgaris L. cv. Felicita) shoot …

Promising anticancer drug thapsigargin: A perspective toward the total synthesis

S Dey, SO Bajaj - Synthetic Communications, 2018 - Taylor & Francis
The guaianolide ring containing sesquiterpene thapsigargin is found in the roots and fruits of
Mediterranean plant Thapsia garganica L. It is known for its activity as a potent antagonist for …

[HTML][HTML] Plant biotechnology in South Africa: Micropropagation research endeavours, prospects and challenges

M Moyo, MW Bairu, SO Amoo, J Van Staden - South African Journal of …, 2011 - Elsevier
Research in plant biotechnology is playing a crucial role in the production and conservation
of plant-based resources globally. Being a country with rich and diverse floral resources …

Natural ventilation effectively reduces hyperhydricity in shoot cultures of Aloe polyphylla Schönland ex Pillans

M Ivanova, J Van Staden - Plant Growth Regulation, 2010 - Springer
An investigation into the role of ventilation to reduce hyperhydricity in tissue cultures of Aloe
polyphylla Schönland ex Pillans revealed that gaseous exchange between the in-vitro …

Promoting root induction and growth of in vitro macadamia (Macadamia tetraphylla L. 'Keaau') plantlets using CO2-enriched photoautotrophic conditions

S Cha-um, C Chanseetis, W Chintakovid… - Plant Cell, Tissue and …, 2011 - Springer
In this study, a rooting protocol was developed for macadamia plantlets with healthy roots
and enhanced growth performance, along with enhanced photosynthetic capability. In vitro …