LIF (leukaemia inhibitory factor) is a key cytokine for maintaining self-renewal and
pluripotency of mESCs (mouse embryonic stem cells). Upon binding to the LIF receptor, LIF …

Neural stem cells (NSCs) have been proposed as a promising cellular source for the
treatment of diseases in nervous systems. NSCs can self-renew and generate major cell …

Multiple cytokines, including interleukin 6 (IL-6), IL-11, IL-27, oncostatin M (OSM), and
leukemia inhibitory factor (LIF), signal via the common GP130 cytokine receptor subunit. In …

Embryonic stem (ES) cells have a unique regulatory circuitry, largely controlled by the
transcription factors Oct4, Sox2, and Nanog, which generates a gene expression program …

Mammalian cells cultured on 2D surfaces in microfluidic channels are increasingly used in
drug development and biological research applications. These systems would have more …

MicroRNAs are small non-coding RNAs that regulate protein expression by binding 3′
UTRs of target mRNAs, thereby inhibiting translation. Similar to siRNAs, miRNAs are …

Neural progenitor cell (NPC) therapy is considered a promising treatment modality for
multiple sclerosis (MS), potentially acting through neural repair. Here, we showed that …

Multi‐potent adult progenitor cells (MAPCs) differentiate into endothelial cells (ECs) in the
presence of vascular endothelial growth factor (VEGF). The mechanism (s) of VEGF …

The posterior signalling centre (PSC), a small group of specialised cells, controls hemocyte
(blood cell) homeostasis in the Drosophila larval hematopoietic organ, the lymph gland. This …

Embryonic stem cells (ES cells) are derived from inner cell mass (ICM). The self‐renewal
and pluripotency are the main specificities of ES cells, which are likely to reveal a deeper …