Introduction Colorectal cancer (CRC) is a devastating disease that affects millions of people
worldwide. Recent research has highlighted the crucial role of the guanylate cyclase-C (GC …

Receptor Guanylyl Cyclase C (GC-C) was initially characterized as an important regulator of
intestinal fluid and ion homeostasis. Recent findings demonstrate that GC-C is also causally …

Activating mutations in receptor guanylyl cyclase C (GC-C), the target of gastrointestinal
peptide hormones guanylin and uroguanylin, and bacterial heat-stable enterotoxins cause …

Alzheimer's disease (AD), the most common neurodegenerative disease and the first cause
of dementia worldwide, has no effective treatment, and its pathological mechanisms are not …

The natriuretic peptides (NPs) hormone family, which consists mainly of atrial, brain, and C-
type NPs (ANP, BNP, and CNP), play diverse roles in mammalian species, ranging from …

Gastric cancer is an intractable malignant tumor that has the fifth highest morbidity and the
third highest mortality in the world. Even though various treatment options did much to …

While impaired intestinal sodium transport has been described for decades as a ubiquitous
feature of inflammatory bowel disease (IBD), whether and how it plays a pivotal role in the …

Mutations in receptor guanylyl cyclase C (GC-C) cause severe gastrointestinal disease,
including meconium ileus, early onset acute diarrhea, and pediatric inflammatory bowel …

Abstract Guanylate cyclase 2C (GC‐C), encoded by the GUCY2C gene, is implicated in
hereditary early onset chronic diarrhea. Several families with chronic diarrhea symptoms …

Cyclic GMP is produced by enzymes called guanylyl cyclases, of which the membrane-
associated forms contain an intracellular pseudokinase domain that allosterically regulates …