Current treatment and recent progress in gastric cancer

SS Joshi, BD Badgwell - CA: a cancer journal for clinicians, 2021 - Wiley Online Library
Gastric cancer is not a top‐10 malignancy in the United States but represents one of the
most common causes of cancer death worldwide. Biological differences between tumors …

Microsatellite instability: a review of what the oncologist should know

K Li, H Luo, L Huang, H Luo, X Zhu - Cancer cell international, 2020 - Springer
The patients with high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR)
tumors recently have been reported that can benefit from immunotherapy, and MSI can be …

Assessment of pembrolizumab therapy for the treatment of microsatellite instability–high gastric or gastroesophageal junction cancer among patients in the KEYNOTE …

J Chao, CS Fuchs, K Shitara, J Tabernero… - JAMA …, 2021 - jamanetwork.com
Importance Immunotherapy has been associated with improved outcomes among patients
who have received previous treatment for microsatellite instability–high (MSI-H) tumors …

Neoadjuvant nivolumab plus ipilimumab and adjuvant nivolumab in localized deficient mismatch repair/microsatellite instability–high gastric or esophagogastric …

T André, D Tougeron, G Piessen… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE In patients with resectable gastric/gastroesophageal junction (GEJ)
adenocarcinoma, surgery plus perioperative platinum-based chemotherapy is the standard …

Mapping the genomic diaspora of gastric cancer

KG Yeoh, P Tan - Nature reviews cancer, 2022 - nature.com
Gastric cancer (GC) is a leading contributor to global cancer incidence and mortality.
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …

Individual patient data meta-analysis of the value of microsatellite instability as a biomarker in gastric cancer

F Pietrantonio, R Miceli, A Raimondi… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE In the CLASSIC and MAGIC trials, microsatellite instability (MSI)–high status was
a favorable prognostic and potential negative predictive factor for neoadjuvant/adjuvant …

DNA mismatch repair in cancer

M Baretti, DT Le - Pharmacology & therapeutics, 2018 - Elsevier
Microsatellite instability (MSI) refers to the hypermutator phenotype secondary to frequent
polymorphism in short repetitive DNA sequences and single nucleotide substitution, as …

[HTML][HTML] Biomarkers of gastric cancer: Current topics and future perspective

T Matsuoka, M Yashiro - World journal of gastroenterology, 2018 - ncbi.nlm.nih.gov
Gastric cancer (GC) is one of the most prevalent malignant types in the world and an
aggressive disease with a poor 5-year survival. This cancer is biologically and genetically …

The Chinese Society of Clinical Oncology (CSCO): clinical guidelines for the diagnosis and treatment of gastric cancer

FH Wang, L Shen, J Li, ZW Zhou, H Liang… - Cancer …, 2019 - Springer
China is one of the countries with the highest incidence of gastric cancer. There are
differences in epidemiological characteristics, clinicopathological features, tumor biological …

[HTML][HTML] Microsatellite instability in Gastric Cancer: Between lights and shadows

E Puliga, S Corso, F Pietrantonio, S Giordano - Cancer treatment reviews, 2021 - Elsevier
Gastric cancer (GC) represents an important contributor to the global burden of cancer,
being one of the most common and deadly malignancies worldwide. According to TCGA and …