[HTML][HTML] Metazoan micrornas

DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

microRNA dysregulation in neurodegenerative diseases: A systematic review

CA Juźwik, SS Drake, Y Zhang, N Paradis-Isler… - Progress in …, 2019 - Elsevier
While the root causes for individual neurodegenerative diseases are distinct, many shared
pathological features and mechanisms contribute to neurodegeneration across diseases …

Clustered miRNAs and their role in biological functions and diseases

SP Kabekkodu, V Shukla, VK Varghese… - Biological …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

The role of microRNAs in neurodegenerative diseases: a review

S Li, Z Lei, T Sun - Cell Biology and Toxicology, 2023 - Springer
MicroRNAs (miRNAs) are non-coding RNAs which are essential post-transcriptional gene
regulators in various neuronal degenerative diseases and playact a key role in these …

MicroRNA degradation by a conserved target RNA regulates animal behavior

A Bitetti, AC Mallory, E Golini, C Carrieri… - Nature structural & …, 2018 - nature.com
Abstract microRNAs (miRNAs) repress target transcripts through partial complementarity. By
contrast, highly complementary miRNA-binding sites within viral and artificially engineered …

Role of MicroRNAs in Parkinson's disease

SY Goh, YX Chao, ST Dheen, EK Tan… - International journal of …, 2019 - mdpi.com
Parkinson's disease (PD) is a disabling neurodegenerative disease that manifests with
resting tremor, bradykinesia, rigidity and postural instability. Since the discovery of …

miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain

E Salta, A Sierksma, E Vanden Eynden… - EMBO molecular …, 2016 - embopress.org
Abstract microRNA‐132 (miR‐132) is involved in prosurvival, anti‐inflammatory and memory‐
promoting functions in the nervous system and has been found consistently downregulated …

Downregulation of blood serum microRNA 29 family in patients with Parkinson's disease

X Bai, Y Tang, M Yu, L Wu, F Liu, J Ni, Z Wang… - Scientific reports, 2017 - nature.com
There is currently no reliable and easily applicable diagnostic marker for Parkinson's
disease (PD). The aims of the present study were to compare the expression profiles of the …

Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology

A Sierksma, A Lu, E Salta, E Vanden Eynden… - Molecular …, 2018 - Springer
Background Despite diverging levels of amyloid-β (Aβ) and TAU pathology, different mouse
models, as well as sporadic AD patients show predictable patterns of episodic memory loss …

[HTML][HTML] Small RNA detection by in situ hybridization methods

MO Urbanek, AU Nawrocka, WJ Krzyzosiak - International journal of …, 2015 - mdpi.com
Small noncoding RNAs perform multiple regulatory functions in cells, and their exogenous
mimics are widely used in research and experimental therapies to interfere with target gene …