The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …

Gelatin methacrylate (GelMA)-based hydrogels are gaining a great deal of attention as
potentially implantable materials in tissue engineering applications because of their …

The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …

Medicine relies on the use of pharmacologically active agents (drugs) to manage and treat
disease. However, drugs are not inherently effective; the benefit of a drug is directly related …

Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …

Abstract Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important
potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute …

Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …

To curb the high cost of drug development, there is an urgent need to develop more
predictive tissue models using human cells to determine drug efficacy and safety in advance …

Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is
associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that …

Study of monogenic mitochondrial cardiomyopathies may yield insights into mitochondrial
roles in cardiac development and disease. Here, we combined patient-derived and …