Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

To date, no effective vaccines or therapies are available against the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), the causative pandemic agent of the coronavirus …

The animal reservoir of SARS-CoV-2 is unknown despite reports of SARS-CoV-2-related
viruses in Asian Rhinolophus bats,,–, including the closest virus from R. affinis, RaTG13 …

Advances in DNA sequencing and machine learning are providing insights into protein
sequences and structures on an enormous scale. However, the energetics driving folding …

Abstract Machine learning-based models of protein fitness typically learn from either
unlabeled, evolutionarily related sequences or variant sequences with experimentally …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity is a major
concern in coronavirus disease 2019 (COVID-19) prevention and economic reopening …

Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known
about the diversity and abundance of viruses within individual bats, and hence the …

Abstract Machine learning has been increasingly used for protein engineering. However,
because the general sequence contexts they capture are not specific to the protein being …

Understanding the effects of mutations on protein stability is crucial for variant interpretation
and prioritisation, protein engineering, and biotechnology. Despite significant efforts …

Proteins are highly dynamic molecules, whose function is intrinsically linked to their
molecular motions. Despite the pivotal role of protein dynamics, their computational …