Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a
class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …

Osteoarthritis (OA) has traditionally been defined as a prototypical non-inflammatory
arthropathy, but today there is compelling evidence to suggest that it has an inflammatory …

Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by
cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms …

OBJECTIVE: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is
widely accepted that synovial inflammation is a feature of OA. However, the role of immune …

Even though osteoarthritis (OA) is mainly considered as a degradative condition of the
articular cartilage, there is increasing body of data demonstrating the involvement of all …

Increased vascular endothelial growth factor (VEGF) levels are associated with osteoarthritis
(OA) progression. Indeed, VEGF appears to be involved in OA‐specific pathologies …

Osteoarthritis (OA) afflicts more than 20 million people in the United States and about 10% of
adults over the age of 50 years [1]. It has been demonstrated that 2.0% of women and 1.4 …

Although osteoarthritis (OA) has been traditionally regarded as a non-inflammatory disease,
reports increasingly suggest that it is inflammatory, at least in certain patients. OA patients …

Cutaneous and systemic hypersensitivity reactions to implanted metals are challenging to
evaluate and treat. Although they are uncommon, they do exist, and require appropriate and …