Nicotinic acetylcholine, serotonin type 3, γ-amminobutyric acid type A, and glycine receptors
are major players of human neuronal communication. They belong to the family of …

Neurotransmitter-gated ion channels of the Cys-loop receptor family are essential mediators
of fast neurotransmission throughout the nervous system and are implicated in many …

Abstract γ-Aminobutyric acid receptors (GABAARs) are vital for controlling excitability in the
brain. This is emphasized by the numerous neuropsychiatric disorders that result from …

The strychnine-sensitive glycine receptor (GlyR) mediates inhibitory synaptic transmission in
the spinal cord and brainstem and is linked to neurological disorders, including autism and …

Type A γ-aminobutyric acid receptors (GABAARs) are inhibitory pentameric ligand-gated ion
channels in the brain. Many anesthetics and neurosteroids act through binding to the …

SLURP-1 is a secreted toxin-like Ly-6/uPAR protein found in epithelium, sensory neurons
and immune cells. Point mutations in the slurp-1 gene cause the autosomal inflammation …

The superfamily of pentameric ligand-gated ion channels (pLGICs) comprises key players in
electrochemical signal transduction across evolution, including historic model systems for …

Individuals with autism spectrum disorder (ASD) exhibit an increased burden of de novo
mutations (DNMs) in a broadening range of genes. While these studies have implicated …

Diminished inhibitory neurotransmission in the superficial dorsal horn of the spinal cord is
thought to contribute to chronic pain. In inflammatory pain, reductions in synaptic inhibition …

Glycine receptors are ligand-gated ion channels that mediate synaptic inhibition throughout
the mammalian spinal cord, brainstem, and higher brain regions. They have recently …