Decision coaching for people making healthcare decisions

J Jull, S Köpke, M Smith, M Carley… - Cochrane Database …, 2021 - cochranelibrary.com
Background Decision coaching is non‐directive support delivered by a healthcare provider
to help patients prepare to actively participate in making a health decision.'Healthcare …

Next-generation service delivery: a scoping review of patient outcomes associated with alternative models of genetic counseling and genetic testing for hereditary …

JM McCuaig, SR Armel, M Care, A Volenik, RH Kim… - Cancers, 2018 - mdpi.com
The combination of increased referral for genetic testing and the current shortage of genetic
counselors has necessitated the development and implementation of alternative models of …

Cost-effectiveness of population-based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 mutation testing in unselected general population women

R Manchanda, S Patel, VS Gordeev… - JNCI: Journal of the …, 2018 - academic.oup.com
Background The cost-effectiveness of population-based panel testing for high-and moderate-
penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is unknown. We …

A cost-effectiveness analysis of multigene testing for all patients with breast cancer

L Sun, A Brentnall, S Patel, DSM Buist… - JAMA …, 2019 - jamanetwork.com
Importance Moving to multigene testing for all women with breast cancer (BC) could identify
many more mutation carriers who can benefit from precision prevention. However, the cost …

Economic Evaluation of Population-Based BRCA1/BRCA2 Mutation Testing across Multiple Countries and Health Systems

R Manchanda, L Sun, S Patel, O Evans, J Wilschut… - Cancers, 2020 - mdpi.com
Clinical criteria/Family history-based BRCA testing misses a large proportion of BRCA
carriers who can benefit from screening/prevention. We estimate the cost-effectiveness of …

Randomised trial of population‐based BRCA testing in Ashkenazi Jews: long‐term outcomes

R Manchanda, M Burnell, F Gaba… - … Journal of Obstetrics …, 2020 - Wiley Online Library
Objective Unselected population‐based BRCA testing provides the opportunity to apply
genomics on a population‐scale to maximise primary prevention for breast‐and‐ovarian …

Disparities in gynecologic cancer genetics evaluation

EM Hinchcliff, EM Bednar, KH Lu, JA Rauh-Hain - Gynecologic oncology, 2019 - Elsevier
Abstract An estimated 2–5% of endometrial cancers and 15–20% of high-grade, non-
mucinous epithelial ovarian cancers have an underlying hereditary cause. Appropriate risk …

Cost-effectiveness of population based BRCA testing with varying Ashkenazi Jewish ancestry

R Manchanda, S Patel, AC Antoniou… - American journal of …, 2017 - Elsevier
Background Population-based BRCA1/BRCA2 testing has been found to be cost-effective
compared with family history–based testing in Ashkenazi-Jewish women were> 30 years old …

Germline BRCA testing in pancreatic cancer: improving awareness, timing, turnaround, and uptake

T Golan, R Casolino, AV Biankin… - Therapeutic …, 2023 - journals.sagepub.com
Prognosis is generally poor for patients with pancreatic ductal adenocarcinoma. However,
patients with germline BRCA1 or BRCA2 mutations (gBRCAm) may benefit from first-line …

Current detection rates and time-to-detection of all identifiable BRCA carriers in the Greater London population

R Manchanda, O Blyuss, F Gaba… - Journal of medical …, 2018 - jmg.bmj.com
Background BRCA carrier identification offers opportunities for early diagnoses, targeted
treatment and cancer prevention. We evaluate BRCA-carrier detection rates in general and …