The development of the fetal heart is exquisitely controlled by a multitude of factors, ranging
from humoral to mechanical forces. The gatekeeper regulating many of these factors is the …

Blood-brain barrier (BBB) integrity is critical for proper function of the central nervous system
(CNS). Here, we show that the endothelial Unc5B receptor controls BBB integrity by …

The first trimester placenta is very rarely investigated for placental vascular formation in
developmental or diseased contexts. Defects in placental formation can cause heart defects …

Stem cell research endeavors to generate specific subtypes of classically defined" cell
types." Here, we generate> 90% pure human artery or vein endothelial cells from pluripotent …

Blood vessel abnormalization alters cancer cell metabolism and promotes cancer
dissemination and metastasis. However, the biological features of the abnormalized blood …

Neuron migration is a hallmark of nervous system development that allows gathering of
neurons from different origins for assembling of functional neuronal circuits. Cortical …

Veins have emerged as the origin of all other endothelial cell subtypes needed to expand
vascular networks during developmental and pathological neoangiogenesis. Here, we …

Abstract The WW-and-C2-domain-containing (WWC) protein family is involved in the
regulation of cell differentiation, cell proliferation, and organ growth control. As upstream …

The roles of fibronectin leucine-rich transmembrane protein 2 (FLRT2) in physiological and
pathological processes are not well known. Here, we identify a potentially novel function of …

Background: The blood brain barrier (BBB) preserves neuronal function in the central
nervous system (CNS) by tightly controlling metabolite exchanges with the blood. In the eye …