Recently, using artificial intelligence (AI) in drug discovery has received much attention
since it significantly shortens the time and cost of developing new drugs. Deep learning (DL) …

The development and application of emerging technologies of Industry 4.0 enable the
realization of digital twins (DT), which facilitates the transformation of the manufacturing …

Aqueous-based film coating has become routine in the pharmaceutical industry. This
process eliminates the use of organic solvents and thus avoids economic, environmental …

Introduction: Pharmaceutical coating processes have generally been transformed from what
was essentially an art form in the mid-twentieth century to a much more technology-driven …

This work presents a novel time-scale extrapolation method to predict the amount and
location of the coating material on tablets based on short discrete element method (DEM) …

Film coating uniformity is an important quality attribute of pharmaceutical tablets. Large
variability in coating thickness can limit process efficiency or cause significant variation in …

Scaling relations for the velocity profile and circulation time, which can be used in design
and scale-up, are of great importance in rotating drums. We conducted simulations by …

Coating of tablets is a common unit operation in the pharmaceutical industry. In most cases,
the final product must meet strict quality requirements; to meet them, a detailed …

Scale up of pan coating process is of high importance to the pharmaceutical and food
industry. The number of process variables and their interdependence in a pan coating …

This paper investigates inter-tablet coating variability, specifically, the variability of tablet
residence times within the spray zone of a horizontal coating pan. Results from experiments …