Deubiquitylating enzymes (DUBs) are proteases that remove the ubiquitin moiety from
ubiquitylated substrates to antagonize the modification mediated by E3 ubiquitin ligases …

A20 is a prototypical anti-inflammatory molecule that is linked to multiple human diseases,
including cancers. The role of A20 as a tumor suppressor was first discovered in B cell …

Purpose: Collagen type I alpha 2 chain (COL1A2) has been shown to participate in the
development of various human malignancies. However, the role of COL1A2 in human …

Gastric cancer (GC) is the third leading cause of cancer-related death worldwide. Very few
therapeutic options are currently available in this neoplasia. The use of 5-Aza-2 …

Autophagy involving core machinery proteins such as ATG9A is part of a cytoprotective
process whose dysregulation is associated with carcinogenesis, neurodegeneration and …

Background Allergic diseases typically refer to a heterogeneous group of conditions
primarily caused by the activation of mast cells or eosinophils, including atopic dermatitis …

TNFα is a pleiotropic cytokine which fuels tumor cell growth, invasion, and metastasis in
some malignancies, while in others it induces cytotoxic cell death. However, the molecular …

Background Although ductal carcinoma in situ (DCIS) is a non-invasive breast cancer, many
DCIS lesions may progress to invasive cancer and the genes and pathways responsible for …

Esophageal cancer (EC) is a serious malignancy and that is the fifth leading cause of cancer-
related death worldwide. Esophageal squamous cell carcinoma (ESCC) is the main subtype …

Introduction Lung cancer is recognized as a highly lethal disease, demanding swift and
accurate solutions. Previous analysis showed the cytotoxic impact of Callyspongia aerizusa …