Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

▪ Abstract Tissue development, differentiation, and physiology require specialized cellular
adhesion and signal transduction at sites of cell-cell contact. Scaffolding proteins that tether …

Voltage-gated calcium channels (CaVs) govern muscle contraction, hormone and
neurotransmitter release, neuronal migration, activation of calcium-dependent signalling …

Sydney Ringer would be overwhelmed today by the implications of his simple experiment
performed over 120 years ago showing that the heart would not beat in the absence of …

Abstract High-voltage-activated Ca2+ channels are essential for diverse biological
processes. They are composed of four or five subunits, including α1, α2-δ, β and γ (ref.) …

Voltage-gated ion channels (VGICs) comprise multiple structural units, the assembly of
which is required for function,. Structural understanding of how VGIC subunits assemble and …

Voltage-dependent calcium channels (VDCC) are multiprotein assemblies that regulate the
entry of extracellular calcium into electrically excitable cells and serve as signal transduction …

The voltage-gated Ca2+ channel β subunit (Cavβ) is a cytosolic auxiliary subunit that plays
an essential role in regulating the surface expression and gating properties of high-voltage …

The idiopathic generalized epilepsies encompass a class of epileptic seizure types that
exhibit a polygenic and heritable etiology. Advances in molecular biology and genetics have …

Voltage‐gated calcium channels (VGCCs) represent the sole mechanism to convert
membrane depolarization into cellular functions like secretion, contraction, or gene …