[HTML][HTML] Recent advances on anticancer activity of coumarin derivatives

A Rawat, AVB Reddy - European Journal of Medicinal Chemistry Reports, 2022 - Elsevier
Coumarin derivatives are important class of natural plant metabolites that offer variety of
biological activities. They can also be derived synthetically, and a wide variety of synthetic …

Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies

M Koley, J Han, VA Soloshonok… - RSC Medicinal …, 2023 - pmc.ncbi.nlm.nih.gov
Many researchers around the world are working on the development of novel anticancer
drugs with different mechanisms of action. In this case, coumarin is a highly promising …

Coumarin-containing hybrids and their anticancer activities

L Zhang, Z Xu - European Journal of Medicinal Chemistry, 2019 - Elsevier
Cancer is the second leading cause of death worldwide, and it results in around 9 million
deaths annually. The anticancer agents play an intriguing role in the treatment of cancers …

Synthetic strategies and pharmacological activities of chromene and its derivatives: An overview

MK Katiyar, GK Dhakad, S Arora, S Bhagat… - Journal of Molecular …, 2022 - Elsevier
Chromene is commonly found in nature and is considered one of the most frequently used
scaffolds in heterocyclic chemistry for the designing of chemical probes for therapeutic and …

Synthesis and biological properties of coumarin derivatives. A review

A Bouhaoui, M Eddahmi, M Dib, M Khouili… - …, 2021 - Wiley Online Library
Coumarin and its derivatives are widely used as scaffolds in the synthesis of new
heterocyclic systems. This review focuses on current developments in the synthesis of …

Design, synthesis, and anti-inflammatory activity of some coumarin Schiff base derivatives: In silico and in vitro study

SJ Hamid, T Salih - Drug Design, Development and Therapy, 2022 - Taylor & Francis
Introduction Inflammation is a fundamental response of the immune system during tissue
damage or pathogen infection to protect and maintain tissue homeostasis. However …

Novel N-Acyl Hydrazone Compounds as Promising Anticancer Agents: Synthesis and Molecular Docking Studies

Y Biliz, B Hasdemir, H Başpınar Küçük… - ACS …, 2023 - ACS Publications
In this study, a new series of N-acyl hydrazones 7a-e, 8a-e, and 9a-e, starting from methyl δ-
oxo pentanoate with different substituted groups 1a-e, were synthesized as anticancer …

Antimycobacterial activity of novel hydrazide-hydrazone derivatives with 2H-chromene and coumarin scaffold

VT Angelova, V Valcheva, NG Vassilev… - Bioorganic & Medicinal …, 2017 - Elsevier
This study reports the synthesis of new 2H-chromene or coumarin based acylhydrazones,
which were evaluated for their in vitro antimycobacterial activity against reference strain …

Synthesis, anti-ferroptosis, anti-quorum sensing, antibacterial and DNA interaction studies of chromene-hydrazone derivatives

AJ Ressler, M Frate, A Hontoria, A Ream… - Bioorganic & medicinal …, 2023 - Elsevier
Nineteen chromene-hydrazone derivatives containing a variety of structural modifications on
the hydrazone moiety were synthesized. Structure-activity correlations were investigated to …

[HTML][HTML] Synthesis and in vitro bioactivity study of new hydrazide-hydrazones of 5-bromo-2-iodobenzoic acid

Ł Popiołek, P Patrejko, M Gawrońska-Grzywacz… - Biomedicine & …, 2020 - Elsevier
In this study 14 novel hydrazide-hydrazones of 5-bromo-2-iodobenzoic acid (3-16) were
synthesized on the basis of condensation reaction. The chemical structure of obtained …