An overview of Nrf2 signaling pathway and its role in inflammation

S Saha, B Buttari, E Panieri, E Profumo, L Saso - Molecules, 2020 - mdpi.com
Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …

The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology

A Rutsch, JB Kantsjö, F Ronchi - Frontiers in immunology, 2020 - frontiersin.org
The human microbiota has a fundamental role in host physiology and pathology. Gut
microbial alteration, also known as dysbiosis, is a condition associated not only with …

IL-17 and IL-17-producing cells in protection versus pathology

KHG Mills - Nature Reviews Immunology, 2023 - nature.com
IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in
the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; …

Inflammasomes in neuroinflammatory and neurodegenerative diseases

S Voet, S Srinivasan, M Lamkanfi… - EMBO molecular …, 2019 - embopress.org
Neuroinflammation and neurodegeneration often result from the aberrant deposition of
aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate …

Interleukin-1 and related cytokines in the regulation of inflammation and immunity

A Mantovani, CA Dinarello, M Molgora, C Garlanda - Immunity, 2019 - cell.com
Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …

Overview of the IL‐1 family in innate inflammation and acquired immunity

CA Dinarello - Immunological reviews, 2018 - Wiley Online Library
Summary The interleukin‐1 (IL‐1) family of cytokines and receptors is unique in immunology
because the IL‐1 family and Toll‐like receptor (TLR) families share similar functions. More …

The pathogenicity of Th17 cells in autoimmune diseases

K Yasuda, Y Takeuchi, K Hirota - Seminars in immunopathology, 2019 - Springer
Abstract IL-17-producing T helper (Th17) cells have been implicated in the pathogenesis of
many inflammatory and autoimmune diseases. Targeting the effector cytokines IL-17 and …

A guiding map for inflammation

MG Netea, F Balkwill, M Chonchol, F Cominelli… - Nature …, 2017 - nature.com
Biologists, physicians and immunologists have contributed to the understanding of the
cellular participants and biological pathways involved in inflammation. Here, we provide a …

[HTML][HTML] Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

EH Kobayashi, T Suzuki, R Funayama… - Nature …, 2016 - nature.com
Abstract Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic
stress response and also represses inflammation. However, the mechanisms how Nrf2 …