It is of considerable translational importance whether depression is a form or a consequence
of sickness behavior. Sickness behavior is a behavioral complex induced by infections and …

Delirium is a common and severe neuropsychiatric syndrome characterised by acute
deterioration and fluctuations in mental status. It is precipitated mainly by acute illness …

Survival depends on an organism's ability to sense nutrient status and accordingly regulate
intake and energy expenditure behaviors. Uncoupling of energy sensing and behavior …

A major development in drug addiction research in recent years has been the discovery that
immune signaling within the central nervous system contributes significantly to mesolimbic …

Adolescence is pivotal for neural and behavioral development across species. During this
period, maturation occurs in several biological systems, the most well-recognized being …

Compelling data demonstrate that inflammation-associated anorexia directly results from the
action of pro-inflammatory factors, primarily cytokines and prostaglandins E2, on the nervous …

Orexin neurons in the lateral hypothalamus constitute a critical component in regulation of
waking, feeding, and reward-related behaviors. In this study we examined the effects of …

Inflammatory molecules, such as cyclooxygenase (COX), a prostaglandin synthetic enzyme,
have been identified as a marker of depressive symptomology. Previously, we have …

Immune challenges can lead to marked behavioral changes, including fatigue, reduced
social interest, anorexia, and somnolence, but the precise neuronal mechanisms that …

Caudal brainstem viscerosensory nuclei convey information about the body's internal state
to forebrain regions implicated in feeding behavior and responses to immune challenge …