Introduction Despite advances in heart failure therapies and percutaneous coronary
interventions, survival for cardiogenic shock remains poor. Percutaneous ventricular assist …

Blood-circulating devices such as oxygenators have offered life-saving opportunities for
advanced cardiovascular and pulmonary failures. However, such systems are limited in the …

The use of mechanical circulatory support using percutaneous ventricular assist devices
(pVAD) has increased rapidly during the last decade without substantial new evidence for …

BACKGROUND: Thrombocytopenia has been consistently described in patients with
extracorporeal membrane oxygenation (ECMO) and associated with poor outcome …

Venovenous extracorporeal membrane oxygenation (ECMO) can be performed with two
single lumen cannulas (SLCs) or one dual-lumen cannula (DLC) where low recirculation …

Despite decades of technological advancements in blood-contacting medical devices,
complications related to shear flow-induced blood trauma are still frequently observed in …

Purpose To develop a mathematical model for predicting shear-induced von Willebrand
factor (vWF) function modification which can be used to guide ventricular assist devices …

Purpose The objective of this study is to develop a bleeding risk model for assessing device-
induced bleeding risk in patients supported with blood contact medical devices (BCMDs) …

Objective Non-physiological shear stress (NPSS) and thrombin have two distinct
mechanisms for activating platelets. NPSS in mechanically assisted circulation (MAC) …

Background Left ventricular assist devices (LVADs) have been used as a standard treatment
option for patients with advanced heart failure. However, these devices are prone to adverse …