The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

Signs and symptoms that are characteristic for depression include changes in the setpoint of
the hypothalamic-pituitary-adrenocortical (HPA) system, which in the majority of these …

Since corticotropin-releasing factor (CRF) was first characterized, a growing family of ligands
and receptors has evolved. The mammalian family members include CRF, urocortinI (UcnI) …

Edited by Gershon Tenenbaum and Robert C. Eklund Copyright© 2007 John Wiley & Sons,
Inc. guidelines that have been established for evaluating overviews of research evidence …

The CRH receptor (CRH-R) is a member of the secretin family of G protein-coupled
receptors. Wide expression of CRH-Rs in the central nervous system and periphery ensures …

Energy balance is maintained via a homeostatic system involving both the brain and the
periphery. A key component of this system is the hypothalamus. Over the past two decades …

Corticotropin-releasing hormone (CRH) is a key regulator of the stress response. This
peptide controls the hypothalamic-pituitary-adrenal (HPA) axis as well as a variety of …

We elucidated the structure of the principle factors regulating the initiation of the acute stress
response in common carp: corticotrophin-releasing hormone (CRH), CRH-receptor 1 (CRH …

The way genetic and/or environmental factors influence psychiatric disorders is an enduring
question in the field of human psychiatric diseases. Anxiety-related disorders provide a …

Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In
mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin …