Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …

The endoplasmic reticulum (ER), which occupies a large portion of the cytoplasm, is the
cell's main site for the biosynthesis of lipids and carbohydrate conjugates, and it is essential …

Lysosomal dysfunction has been increasingly linked to disease and normal ageing,.
Lysosomal membrane permeabilization (LMP), a hallmark of lysosome-related diseases …

Lysosome integrity is essential for cell viability, and lesions in lysosome membranes are
repaired by the ESCRT machinery. Here, we describe an additional mechanism for …

During macroautophagic stress, autophagosomes can be produced continuously and in
high numbers. Many different organelles have been reported as potential donor membranes …

Lipids are distributed in a highly heterogeneous fashion in different cellular membranes.
Only a minority of lipids achieve their final intracellular distribution through transport by …

Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the
mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 …

The lipid composition of cellular organelles is tailored to suit their specialized tasks. A
fundamental transition in the lipid landscape divides the secretory pathway in early and late …

Summary VAP (VAPA and VAPB) is an evolutionarily conserved endoplasmic reticulum (ER)-
anchored protein that helps generate tethers between the ER and other membranes through …

Lipid transfer between cell membrane bilayers at contacts between the endoplasmic
reticulum (ER) and other membranes help to maintain membrane lipid homeostasis. We …