In some patients, the inflammatory‐immune response to surgical injury progresses to a
harmful, dysregulated state. We posit that postoperative systemic inflammatory dysregulation …

Importance Intravenous iron is recommended by many clinical guidelines based largely on
its effectiveness in reducing anemia. However, the association with important safety …

Traditional surgical outcome measures include minor and major complications, hospital
length of stay and sometimes longer‐term survival. Each of these is important but there …

Background Outcome selection underpins clinical trial interpretation. Inconsistency in
outcome selection and reporting hinders comparison of different trials' results, reducing the …

Background/importance There is heterogeneity among the outcomes used in regional
anesthesia research. Objective We aimed to produce a core outcome set for regional …

Background Anaemia is common and associated with poor outcomes in survivors of critical
illness. However, the optimal treatment strategy is unclear. Methods We conducted a …

Background Intraoperative hypotension is common in patients having non-cardiac surgery
and is associated with serious complications and death. However, optimal intraoperative …

Systematic reviews and meta-analyses (SRMAs) are increasing in popularity, but should
they be used to inform clinical decision-making in anaesthesia? We present evidence that …

Background Surgery is the primary treatment that can offer potential cure for gastric cancer,
but is associated with significant risks. Identifying optimal surgical approaches should be …

A firm concept of time is essential for establishing causality in a clinical setting. Review of
critical incidents and generation of study hypotheses require a robust understanding of the …