Neurodegenerative diseases are adult-onset neurological conditions that are notoriously
difficult to model for drug discovery and development because most models are unable to …

Simple Summary The cell division cycle is tightly regulated to ensure faithful and complete
DNA replication. A critical cell cycle phase is G1 in which cells prepare DNA for replication in …

Germline mutations in the BRCA genes are associated with a higher risk of carcinogenesis,
which is linked to an increased mutation rate and loss of the second unaffected BRCA allele …

Replication stress (RS) is a hallmark of cancer cells that is associated with increased
genomic instability. RS occurs when replication forks encounter obstacles along the DNA …

Customizable manufacturing of ex vivo cell engineering is driven by the need for innovations
in the biomedical field and holds substantial potential for addressing current therapeutic …

Organisms are complex assemblages of cells, cells that produce light, shoot harpoons, and
secrete glue. Therefore, identifying the mechanisms that generate novelty at the level of the …

Natural killer (NK) cell deficiency (NKD) is a rare disease in which NK cell function is
reduced, leaving affected individuals susceptible to repeated viral infections and cancer …

The prevalence of cardiovascular disease varies with sex, and the impact of intrinsic sex-
based differences on vasculature is not well understood. Animal models can provide …

Substantial background level of replication stress is a feature of embryonic and induced
pluripotent stem cells (iPSCs), which can predispose to numerical and structural …

Pluripotent stem cells (PSCs) are important for future regenerative medicine therapies.
However, in the production of PSCs and derivatives, the control of culture-induced …