The gastrointestinal tract has the important task of absorbing nutrients, a complex process
that requires an intact barrier allowing the passage of nutrients but that simultaneously …

Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by
eosinophilic infiltration of the esophagus. It arises from a complex interplay of genetic …

New types of protein sources will enter our diet in a near future, reinforcing the need for a
straightforward in vitro (cell‐based) screening model to test and predict the safety of these …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology
that can affect nearly every organ system in the body. Besides genetic and environmental …

Abstract Background Interleukin (IL)‐33 is an upstream regulator of type 2 (T2) eosinophilic
inflammation and has been proposed as a key driver of some asthma phenotypes. Objective …

Celiac disease (CD) is a chronic autoimmune disease characterized by an immune-
triggered enteropathy upon gluten intake. The only current treatment available is lifelong …

Abstract IL-33, an epithelial-derived cytokine, functions as an alarmin for the immune system
in the tumor microenvironment (TME). However, the expression and role of IL-33 on cervical …

Rheumatoid arthritis (RA) is a chronic autoimmune disease that occurs mainly in synovial
joints, causing synovial inflammation and joint injury. If diagnosed and treated in time, the …

The small intestine has a high rate of cell turnover under homeostatic conditions, and this
increases further in response to infection or damage. Epithelial cells mostly die by apoptosis …

Usually, the massive elimination of cells under steady-state conditions occurs by apoptosis,
which is also acknowledged to explain the loss of enterocytes in the small intestine of celiac …