During the past decades, mass spectrometry (MS)-based proteomics has become an
important technology to identify protein–protein interactions (PPIs). The application of a …

Cellular functions are the result of the coordinated action of groups of proteins interacting in
molecular assemblies or pathways. The systematic and unbiased charting of protein–protein …

Determining the composition of protein complexes is an essential step toward
understanding the cell as an integrated system. Using coaffinity purification coupled to mass …

The formation and plasticity of synaptic connections rely on regulatory interactions between
pre-and postsynaptic cells. We show that the Drosophila heparan sulfate proteoglycans …

The formation and function of cilia involves the movement of intraflagellar transport (IFT)
particles underneath the ciliary membrane, along axonemal microtubules,. Although this …

Signalling activity of the Notch receptor, which plays a fundamental role in metazoan cell
fate determination, is controlled at multiple levels. We uncovered a Notch signal-controlling …

The four divergent serotypes of dengue virus are the causative agents of dengue fever,
dengue hemorrhagic fever and dengue shock syndrome. About two-fifths of the world's …

DSL ligands promote proteolysis of the Notch receptor, to release active Notch intracellular
domain (N ICD). Conversely, the E3 ubiquitin ligase Deltex can activate ligand-independent …

Isolation and identification of protein partners in multi-protein complexes are important in
gaining further insights into the cellular roles of proteins and determining the possible …

Protein–protein interactions were investigated for α-chymotrypsinogen by static and dynamic
light scattering (SLS and DLS, respectively), as well as small-angle neutron scattering …