Malaria in pregnancy: from placental infection to its abnormal development and damage

CLL Chua, SKM Khoo, JLE Ong… - Frontiers in …, 2021 - frontiersin.org
Malaria remains a global health burden with Plasmodium falciparum accounting for the
highest mortality and morbidity. Malaria in pregnancy can lead to the development of …

Sequestration and tissue accumulation of human malaria parasites: can we learn anything from rodent models of malaria?

B Franke-Fayard, J Fonager, A Braks, SM Khan… - PLoS …, 2010 - journals.plos.org
The sequestration of Plasmodium falciparum–infected red blood cells (irbcs) in the
microvasculature of organs is associated with severe disease; correspondingly, the …

The role of animal models for research on severe malaria

AG Craig, GE Grau, C Janse, JW Kazura… - PLoS …, 2012 - journals.plos.org
In light of the recent controversies over the role of animal models for research into the
development of new treatments for severe malaria, particularly cerebral disease, a group of …

From mice to women: the conundrum of immunity to infection during pregnancy

L Krishnan, T Nguyen, S McComb - Journal of reproductive immunology, 2013 - Elsevier
Resistance to infection is the ability of the host to evoke a strong immune response sufficient
to eliminate the infectious agent. In contrast, maternal tolerance to the fetus necessitates …

Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

NM Zin, MS Baba, AH Zainal-Abidin… - Drug Design …, 2017 - Taylor & Francis
Endophytic Streptomyces strains are potential sources for novel bioactive molecules. In this
study, the diketopiperazine gancidin W (GW) was isolated from the endophytic …

TLR4-mediated placental pathology and pregnancy outcome in experimental malaria

R Barboza, FA Lima, AS Reis, OJ Murillo… - Scientific Reports, 2017 - nature.com
Malaria-associate pregnancy has a significant impact on infant morbidity and mortality. The
detrimental effects of malaria infection during pregnancy have been shown to correlate with …

Malaria infections: what and how can mice teach us

V Zuzarte-Luis, MM Mota, AM Vigário - Journal of immunological methods, 2014 - Elsevier
Malaria imposes a horrific public health burden–hundreds of millions of infections and
millions of deaths–on large parts of the world. While this unacceptable health burden and its …

Of mice and women: rodent models of placental malaria

L Hviid, CRF Marinho, T Staalsoe… - Trends in …, 2010 - cell.com
Pregnant women are at increased malaria risk. The infections are characterized by placental
accumulation of infected erythrocytes (IEs) with adverse consequences for mother and baby …

Intravital Placenta Imaging Reveals Microcirculatory Dynamics Impact on Sequestration and Phagocytosis of Plasmodium-Infected Erythrocytes

LV de Moraes, CE Tadokoro, I Gómez-Conde… - PLoS …, 2013 - journals.plos.org
Malaria in pregnancy is exquisitely aggressive, causing a range of adverse maternal and
fetal outcomes prominently linked to Plasmodium-infected erythrocyte cytoadherence to fetal …

Malaria in pregnancy: the relevance of animal models for vaccine development

J Doritchamou, A Teo, M Fried, PE Duffy - Lab animal, 2017 - nature.com
Malaria during pregnancy due to Plasmodium falciparum or P. vivax is a major public health
problem in endemic areas, with P. falciparum causing the greatest burden of disease …