Approximately 7% of men suffer from fertility problems, the etiology of which are ascribable
to a number of factors acting at pretesticular, posttesticular, or testicular levels. About 20% of …

Azoospermia affects 1% of men, and it can be due to:(i) hypothalamic-pituitary
dysfunction,(ii) primary quantitative spermatogenic disturbances,(iii) urogenital duct …

Non-obstructive azoospermia (NOA) is a severe and frequent cause of male infertility, often
treated by testicular sperm extraction followed by intracytoplasmic sperm injection. The aim …

Asthenozoospermia is a common cause of male infertility, but its etiology remains
incompletely understood. We recruited three Pakistani infertile brothers, born to first-cousin …

It is estimated that one in 100 men have azoospermia, the complete lack of sperm in the
ejaculate. Currently,~ 20% of azoospermia cases remain idiopathic. Non-obstructive …

Human infertility is a multifactorial disease that affects 8%–12% of reproductive-aged
couples worldwide. However, the genetic causes of human infertility are still poorly …

BACKGROUND Our genetic code is now readable, writable and hackable. The recent
escalation of genome-wide sequencing (GS) applications in population diagnostics will not …

Fanconi anemia (FA) is a life-threatening syndrome characterized by bone marrow failure
and cancer predispositions. The past two decades have seen an explosion of data in the FA …

Non-Obstructive Azoospermia (NOA) affects about 1% of men in the general population and
is characterized by clinical heterogeneity implying the involvement of several different …

Genetic anomalies are known to affect about 15% of infertile patients with azoospermia or
severe oligozoospermia. Despite a throughout diagnostic work-up, in up to the 72% of the …