Polyphenols in metabolic diseases

A Gasmi, PK Mujawdiya, S Noor, R Lysiuk… - Molecules, 2022 - mdpi.com
Polyphenols (PPs) are a large group of phytochemicals containing phenolic rings with two or
more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic …

Small molecules regulating reactive oxygen species homeostasis for cancer therapy

J Zhang, D Duan, ZL Song, T Liu… - Medicinal Research …, 2021 - Wiley Online Library
Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

[HTML][HTML] Natural exosome-like nanovesicles from edible tea flowers suppress metastatic breast cancer via ROS generation and microbiota modulation

Q Chen, Q Li, Y Liang, M Zu, N Chen… - … Pharmaceutica Sinica B, 2022 - Elsevier
Although several artificial nanotherapeutics have been approved for practical treatment of
metastatic breast cancer, their inefficient therapeutic outcomes, serious adverse effects, and …

Tea leaf-derived exosome-like nanotherapeutics retard breast tumor growth by pro-apoptosis and microbiota modulation

Q Chen, M Zu, H Gong, Y Ma, J Sun, S Ran… - Journal of …, 2023 - Springer
While several artificial nanodrugs have been approved for clinical treatment of breast tumor,
their long-term applications are restricted by unsatisfactory therapeutic outcomes, side …

[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

J Egea, I Fabregat, YM Frapart, P Ghezzi, A Görlach… - Redox biology, 2017 - Elsevier
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

Inhibition of cancer antioxidant defense by natural compounds

A Sznarkowska, A Kostecka, K Meller… - Oncotarget, 2016 - pmc.ncbi.nlm.nih.gov
All classic, non-surgical anticancer approaches like chemotherapy, radiotherapy or
photodynamic therapy kill cancer cells by inducing severe oxidative stress. Even tough …

Hepatoprotective effect of kaempferol: a review of the dietary sources, bioavailability, mechanisms of action, and safety

MY Alkandahri, BT Pamungkas… - Advances in …, 2023 - Wiley Online Library
The liver is the body's most critical organ that performs vital functions. Hepatic disorders can
affect the physiological and biochemical functions of the body. Hepatic disorder is a …

[HTML][HTML] Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer

L Andrisic, D Dudzik, C Barbas, L Milkovic, T Grune… - Redox biology, 2018 - Elsevier
Association of oxidative stress with carcinogenesis is well known, but not understood well,
as is pathophysiology of oxidative stress generated during different types of anti-cancer …

Review and chemoinformatic analysis of ferroptosis modulators with a focus on natural plant products

V Stepanić, M Kučerová-Chlupáčová - Molecules, 2023 - mdpi.com
Ferroptosis is a regular cell death pathway that has been proposed as a suitable therapeutic
target in cancer and neurodegenerative diseases. Since its definition in 2012, a few hundred …

Unraveling the anticancer effect of curcumin and resveratrol

AR Pavan, GDB Silva, DH Jornada, DE Chiba… - Nutrients, 2016 - mdpi.com
Resveratrol and curcumin are natural products with important therapeutic properties useful
to treat several human diseases, including cancer. In the last years, the number of studies …