Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …

The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Neuropathic pain is a leading cause of high-impact pain, is often disabling and is poorly
managed by current therapeutics. Here we focused on a unique group of neuropathic pain …

SARS-CoV-2 is a novel coronavirus that infects cells through the angiotensin-converting
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …

Chronic itch is a major symptom of many inflammatory skin diseases. This type of pruritus is
thought to be facilitated by cytokines that activate cutaneous nerve fibers; however, the …

Primary and metastatic cancers that affect bone are frequently associated with severe and
intractable pain. The mechanisms underlying the pathogenesis of bone cancer pain still …

The specific functions of sensory systems depend on the tissue-specific expression of genes
that code for molecular sensor proteins that are necessary for stimulus detection and …

Injuries and diseases of the peripheral nervous system (PNS) are common but frequently
irreversible. It is often but mistakenly assumed that peripheral neuron regeneration is robust …

Glycoprotein 130 (gp130) is the signal transducing receptor subunit for cytokines of the
interleukin-6 (IL-6) family, and it is expressed in a multitude of cell types of the immune and …

Pruritus is a common and painful symptom in psoriasis with profoundly negative impacts on
quality of life. The underlying mechanisms of pruritus are complex and multifactorial, and …