Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …

Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …

One of the most amazing findings in molecular biology was the discovery that eukaryotic
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …

The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …

Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …

The genomic distribution of cleavage and polyadenylation (polyA) sites should be co-
evolutionally optimized with the local gene structure. Otherwise, spurious polyadenylation …

The concept of early termination as an important means of transcriptional control has long
been established. Even so, its role in metazoan gene expression is underappreciated …

Cleavage and polyadenylation (pA) is a fundamental step that is required for the maturation
of primary protein encoding transcripts into functional mRNAs that can be exported from the …

What drives the flow of signals controlling the outcome of post-transcriptional regulation of
gene expression? This regulatory layer, presiding to processes ranging from splicing to …

Chromodomain helicase DNA binding protein 2 (Chd2) is a chromatin remodeller implicated
in neurological disease. Here we show that Chaserr, a highly conserved long noncoding …