Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element
binding proteins (SREBPs). In addition to performing canonical functions in the …

The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to
produce sterols and isoprenoids that are integral to tumour growth and progression. In …

Sterol regulatory element binding protein-2 (SREBP-2) is activated by cytokines or
pathogen, such as virus or bacteria, but its association with diminished cholesterol levels in …

Sterol Regulatory Element Binding Protein-1c is a transcription factor that controls the
synthesis of lipids from glucose in the liver, a process which is of utmost importance for the …

Recent advances have significantly increased our understanding of how sterol regulatory
element binding proteins (SREBPs) are regulated at the transcriptional and post …

Lipogenesis in liver is highest in the postprandial state; insulin activates SREBP-1c, which
transcriptionally activates genes involved in FA synthesis, whereas glucose activates …

Circadian rhythms are intimately linked to cellular metabolism. Specifically, the NAD+-
dependent deacetylase SIRT1, the founding member of the sirtuin family, contributes to …

Sterol regulatory element-binding proteins (SREBPs) belong to a family of transcription
factors that regulate the expression of genes required for the synthesis of fatty acids and …

Fatty liver disease is associated with obesity and type 2 diabetes, and hepatic lipid
accumulation may contribute to insulin resistance. Histone deacetylase 3 (Hdac3) controls …

The upsurge in prevalence of obesity has spawned an epidemic of nonalcoholic fatty liver
disease (NAFLD). Previously, we identified a sequence variant (I148M) in patatin-like …