Drug transporter expression profiling in a three-dimensional kidney proximal tubule in vitro nephrotoxicity model
D Diekjürgen, DW Grainger - Pflügers Archiv-European Journal of …, 2018 - Springer
Given currently poor toxicity translational predictions for drug candidates, improved
mechanistic understanding underlying nephrotoxicity and drug renal clearance is needed to …
mechanistic understanding underlying nephrotoxicity and drug renal clearance is needed to …
Validating an ex vivo 3D kidney proximal tubule model for drug-induced nephrotoxicity screening
DEL Diekjurgen - 2017 - search.proquest.com
Kidney toxicity is the second highest cause of new drug candidate failure, after liver toxicity,
leading to drug withdrawals from the market and failed clinical trials. Therefore, development …
leading to drug withdrawals from the market and failed clinical trials. Therefore, development …