Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Inositol phospholipids have long been known to have an important regulatory role in cell
physiology. The repertoire of cellular processes known to be directly or indirectly controlled …

Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by
90 genes in the human genome. Here, we present the set of 107 genes in the human …

Amyotrophic lateral sclerosis (ALS) is a paralytic disorder caused by motor neuron
degeneration. Mutations in more than 50 human genes cause diverse types of motor neuron …

Charcot-Marie-Tooth (CMT) neuropathies comprise a group of monogenic disorders
affecting the peripheral nervous system. CMT is characterized by a clinically and genetically …

Intellectual disability (ID), also referred to as mental retardation (MR), is frequently the result
of genetic mutation. Where ID is present together with additional clinical symptoms or …

Mutations of the lipid phosphatase FIG4 that regulates PI (3, 5) P 2 are responsible for the
recessive peripheral-nerve disorder CMT4J. We now describe nonsynonymous variants of …

Membrane-bound phosphoinositides are signalling molecules that have a key role in vesicle
trafficking in eukaryotic cells. Proteins that bind specific phosphoinositides mediate …

Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

The Charcot-Marie-Tooth (CMT) disorders comprise a group of clinically and genetically
heterogeneous hereditary motor and sensory neuropathies, which are mainly characterized …