Risk factors and biomarkers of age-related macular degeneration

NG Lambert, H ElShelmani, MK Singh… - Progress in retinal and …, 2016 - Elsevier
A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

[HTML][HTML] Congenital aniridia beyond black eyes: from phenotype and novel genetic mechanisms to innovative therapeutic approaches

A Daruich, M Duncan, MP Robert, N Lagali… - Progress in retinal and …, 2023 - Elsevier
Congenital PAX6-aniridia, initially characterized by the absence of the iris, has progressively
been shown to be associated with other developmental ocular abnormalities and systemic …

[HTML][HTML] Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs

J Krol, V Busskamp, I Markiewicz, MB Stadler, S Ribi… - Cell, 2010 - cell.com
Adaptation to different levels of illumination is central to the function of the retina. Here, we
demonstrate that levels of the miR-183/96/182 cluster, miR-204, and miR-211 are regulated …

MicroRNA-200b regulates vascular endothelial growth factor–mediated alterations in diabetic retinopathy

K McArthur, B Feng, Y Wu, S Chen, S Chakrabarti - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Diabetic retinopathy (DR) is a leading cause of blindness. Increased vascular
endothelial growth factor (VEGF), promoting angiogenesis and increased permeability, is a …

[HTML][HTML] MicroRNAs in early diabetic retinopathy in streptozotocin-induced diabetic rats

B Kovacs, S Lumayag, C Cowan… - … ophthalmology & visual …, 2011 - iovs.arvojournals.org
Purpose.: Diabetic retinopathy (DR) is one of the leading causes of blindness. However, the
roles of microRNAs (miRNAs) in DR are still unknown. The aims of this study were to identify …

Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration

S Lumayag, CE Haldin, NJ Corbett… - Proceedings of the …, 2013 - National Acad Sciences
The microRNA-183/96/182 cluster is highly expressed in the retina and other sensory
organs. To uncover its in vivo functions in the retina, we generated a knockout mouse model …

[HTML][HTML] Sequence Relationships among C. elegans, D. melanogaster and Human microRNAs Highlight the Extensive Conservation of microRNAs in Biology

C Ibáñez-Ventoso, M Vora, M Driscoll - PloS one, 2008 - journals.plos.org
microRNAs act in a prevalent and conserved post-transcriptional gene regulatory
mechanism that impacts development, homeostasis and disease, yet biological functions for …

[HTML][HTML] Deep sequencing of small RNA libraries reveals dynamic regulation of conserved and novel microRNAs and microRNA-stars during silkworm development

G Jagadeeswaran, Y Zheng, N Sumathipala, H Jiang… - BMC genomics, 2010 - Springer
Abstract Background In eukaryotes, microRNAs (miRNAs) have emerged as critical
regulators of gene expression. The Silkworm (Bombyx mori L.) is one of the most suitable …

[HTML][HTML] miRNeye: a microRNA expression atlas of the mouse eye

M Karali, I Peluso, VA Gennarino, M Bilio, R Verde… - BMC genomics, 2010 - Springer
Background MicroRNAs (miRNAs) are key regulators of biological processes. To define
miRNA function in the eye, it is essential to determine a high-resolution profile of their spatial …

Aberrant expression of serum miRNAs in schizophrenia

W Shi, J Du, Y Qi, G Liang, T Wang, S Li, S Xie… - Journal of psychiatric …, 2012 - Elsevier
The circulating miRNAs are sufficiently stable and detectable to serve as clinical biomarkers
as recent studies have revealed that the aberrant expression of circulating miRNAs can …