The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in infected and
malignant cells and catalyzes the formation of 2′ 3′ cGMP-AMP (cGAMP), which in turn …

Ca 2+-permeable channels that are involved in the responses of mammalian cells to
changes in extracellular osmolarity have not been characterized at the molecular level. Here …

Endothelial cells (EC) form a unique signal-transducing surface in the vascular system. The
abundance of ion channels in the plasma membrane of these nonexcitable cells has raised …

Volume-regulated anion channels are activated in response to hypotonic stress. These
channels are composed of closely related paralogues of the leucine-rich repeat-containing …

A fundamental property of animal cells is the ability to regulate their own cell volume. Even
under hypotonic stress imposed by either decreased extracellular or increased intracellular …

The development of treatments for neuropathic pain has been hindered by our limited
understanding of the basic mechanisms underlying abnormalities in nociceptor …

The volume-regulated anion channel (VRAC), also known as the volume-sensitive
outwardly rectifying (VSOR) anion channel or the volume-sensitive organic osmolyte/anion …

Although the transient receptor potential vanilloid 4 (TRPV4) has been implicated in the
process of osmomechanical transduction, it appears to make little contribution to the normal …