Exploring the interplay between polyphenols and lysyl oxidase enzymes for maintaining extracellular matrix homeostasis

C Añazco, J Riedelsberger, L Vega-Montoto… - International Journal of …, 2023 - mdpi.com
Collagen, the most abundant structural protein found in mammals, plays a vital role as a
constituent of the extracellular matrix (ECM) that surrounds cells. Collagen fibrils are …

LOXL2 in cancer: a two-decade perspective

A Cano, P Eraso, MJ Mazón, F Portillo - International Journal of Molecular …, 2023 - mdpi.com
Lysyl Oxidase Like 2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises
five lysine tyrosylquinone (LTQ)-dependent copper amine oxidases in humans. In 2003 …

A 3D–Predicted Structure of the Amine Oxidase Domain of Lysyl Oxidase–Like 2

AA Meier, K Kuczera, M Mure - International Journal of Molecular …, 2022 - mdpi.com
Lysyl oxidase–like 2 (LOXL2) has been recognized as an attractive drug target for anti–
fibrotic and anti–tumor therapies. However, the structure–based drug design of LOXL2 has …

Multifunctional Lysyl Oxidases

PC Trackman - International Journal of Molecular Sciences, 2023 - mdpi.com
This Special Issue on lysyl oxidases, which are proteins derived from five related genes
known as Lox, and Loxl1–Loxl4, brings together articles that reflect some of the diverse …

Lysyl oxidases as targets for cancer therapy and diagnostic imaging

R Löser, M Kuchar, R Wodtke, C Neuber… - …, 2023 - Wiley Online Library
The understanding of the contribution of the tumour microenvironment to cancer progression
and metastasis, in particular the interplay between tumour cells, fibroblasts and the …

Conformation Changes Associated with the Formation and Activation of Lysine Tyrosylquinone of LOXL2 Studied by Metadynamics Simulation

Y Wang, L Lin, LY Xu, EM Li… - Advanced Theory and …, 2024 - Wiley Online Library
Abstract Lysyl oxidase‐like 2 (LOXL2) is a Cu2+‐dependent amine oxidase that catalyzes
the oxidative deamination of lysine residues of elastin and collagen to generate aldehyde …

[PDF][PDF] Crystal structures of di-μ-chlorido-bis ({(E)-5-(ethylamino)-4-methyl-2-[(pyridin-2-yl) diazenyl] phenolato} copper (II)) and chloridobis (1, 10-phenanthroline) …

A Meier, MR Mian, S Ou, S Lovell… - Acta Crystallographica …, 2023 - journals.iucr.org
The dark-red title complex crystallized from an equimolar methanol solution of (E)-5-
(ethylamino)-4-methyl-2-[(pyridin-2-yl) diazenyl] phenol and CuCl2 (phen)(phen= 1, 10 …

Exploring the interplay between polyphenols and lysyl oxidase enzymes for maintaining extracellular matrix homeostasis

C Añazco-Oyarzún, J Riedelsberger, L Vega-Montoto… - 2023 - repositorio.ucm.cl
Collagen, the most abundant structural protein found in mammals, plays a vital role as a
constituent of the extracellular matrix (ECM) that surrounds cells. Collagen fibrils are …