Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …

Significant advances in materials, microscale technology, and stem cell biology have
enabled the construction of 3D tissues and organs, which will ultimately lead to more …

To curb the high cost of drug development, there is an urgent need to develop more
predictive tissue models using human cells to determine drug efficacy and safety in advance …

This review covers several aspects of microfluidic devices used for culturing and monitoring
of both adherent and non-adherent cells, including a multitude of applications. A comparison …

The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …

Hyaluronic acid (HA)‐based biomaterials have been explored for a number of applications
in biomedical engineering, particularly as tissue regeneration scaffolds. Crosslinked forms of …

The superiority of in vitro 3D cultures over conventional 2D cell cultures is well recognized
by the scientific community for its relevance in mimicking the native tissue architecture and …

Translational challenges associated with reductionist modeling approaches, as well as
ethical concerns and economic implications of small animal testing, drive the need for …

Cell‐based living materials, including single cells, cell‐laden fibers, cell sheets, organoids,
and organs, have attracted intensive interests owing to their widespread applications in …

Future drug discovery and toxicology testing could benefit significantly from more predictive
and multi-parametric readouts from in vitro models. Despite the recent advances in the field …