Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention

S Mirzaei, MDA Paskeh, E Okina, MH Gholami… - Journal of Experimental …, 2022 - Springer
Background One of the most malignant tumors in men is prostate cancer that is still incurable
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …

Mechanisms of long non-coding RNAs in cancers and their dynamic regulations

XZ Zhang, H Liu, SR Chen - Cancers, 2020 - mdpi.com
Long non-coding RNA (lncRNA), which is a kind of noncoding RNA, is generally
characterized as being more than 200 nucleotide transcripts in length. LncRNAs exhibit …

Long non-coding RNAs in prostate cancer: Functional roles and clinical implications

YH Xu, JL Deng, G Wang, YS Zhu - Cancer letters, 2019 - Elsevier
Long noncoding RNAs (lncRNAs) are defined as RNA transcripts longer than 200
nucleotides that do not encode proteins. LncRNAs have been documented to exhibit …

Loss of Long Noncoding RNA NXTAR in Prostate Cancer Augments Androgen Receptor Expression and Enzalutamide Resistance

R Ghildiyal, M Sawant, A Renganathan, K Mahajan… - Cancer research, 2022 - AACR
Androgen receptor (AR) signaling continues to play a dominant role in all stages of prostate
cancer, including castration-resistant prostate cancers (CRPC) that have developed …

Long non-coding RNAs in colorectal cancer: navigating the intersections of immunity, intercellular communication, and therapeutic potential

NK Shakhpazyan, LM Mikhaleva, AL Bedzhanyan… - Biomedicines, 2023 - mdpi.com
This comprehensive review elucidates the intricate roles of long non-coding RNAs
(lncRNAs) within the colorectal cancer (CRC) microenvironment, intersecting the domains of …

Keep your eyes peeled for long noncoding RNAs: Explaining their boundless role in cancer metastasis, drug resistance, and clinical application

GK Barik, O Sahay, A Behera, D Naik… - Biochimica et Biophysica …, 2021 - Elsevier
Cancer metastasis and drug resistance are two major obstacles in the treatment of cancer
and therefore, the leading cause of cancer-associated mortalities worldwide. Hence, an in …

Fatty acid β-oxidation promotes breast cancer stemness and metastasis via the miRNA-328-3p-CPT1A pathway

F Zeng, M Yao, Y Wang, W Zheng, S Liu, Z Hou… - Cancer gene …, 2022 - nature.com
MicroRNAs (miRNA) have been shown to be associated with tumor diagnosis, prognosis,
and therapeutic response. MiR-328-3p plays a significant role in breast cancer growth; …

Down‐regulated LINC00115 inhibits prostate cancer cell proliferation and invasion via targeting miR‐212‐5p/FZD5/Wnt/β‐catenin axis

N Peng, Z Zhang, Y Wang, M Yang… - Journal of Cellular …, 2021 - Wiley Online Library
Prostate cancer is the second most frequent malignancy in men worldwide, and its incidence
is increasing. Therefore, it is urgently required to clarify the underlying mechanisms of …

Knockdown of LncRNA SNHG7 inhibited epithelial-mesenchymal transition in prostate cancer though miR-324-3p/WNT2B axis in vitro

H Hu - Pathology-Research and Practice, 2019 - Elsevier
It is identified that long non-coding RNAs (lncRNAs) play important roles in cancer
progression and metastasis. LncRNA SNHG7 was reported to play an oncogenic role in the …

[HTML][HTML] Long noncoding RNA MIR4435-2HG promotes hepatocellular carcinoma proliferation and metastasis through the miR-22-3p/YWHAZ axis

X Shen, Y Ding, F Lu, H Yuan… - American journal of …, 2020 - ncbi.nlm.nih.gov
Long noncoding RNAs (lncRNAs) play the critical biological role in many malignant tumours.
MIR4435-2HG has been proven to be a novel oncogenic lncRNA. However, the exact role …