In vitro-produced bovine embryos—Dealing with the warts

P Lonergan, T Fair - Theriogenology, 2008 - Elsevier
Bovine in vitro embryo production is an inefficient process; while maturation and fertilization
proceed apparently normally, the proportion of embryos reaching the transferable …

Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights

V Van Hoeck, J Leroy, MA Alvarez, D Rizos… - …, 2013 - rep.bioscientifica.com
The aim of this study was to evaluate the distribution of inhibin/activin alpha, beta (A) and
beta (B) subunits and follistatin in immature oocytes and in matured oocytes before and after …

[HTML][HTML] Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: a retrospective cohort …

M Meseguer, I Rubio, M Cruz, N Basile, J Marcos… - Fertility and sterility, 2012 - Elsevier
OBJECTIVE: To quantify the effect on reproductive outcome of culturing and selecting
embryos using a novel time-lapse monitoring system (TMS). DESIGN: Retrospective …

Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology

V Van Hoeck, RG Sturmey, P Bermejo-Alvarez… - PloS one, 2011 - journals.plos.org
Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal
disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment …

The enigmatic morula: mechanisms of development, cell fate determination, self-correction and implications for ART

G Coticchio, C Lagalla, R Sturmey… - Human reproduction …, 2019 - academic.oup.com
BACKGROUND Assisted reproduction technology offers the opportunity to observe the very
early stages of human development. However, due to practical constraints, for decades …

Oxygen consumption and ROS production are increased at the time of fertilization and cell cleavage in bovine zygotes

AS Lopes, M Lane, JG Thompson - Human reproduction, 2010 - academic.oup.com
BACKGROUND Oxygen consumption is a key indicator of metabolic activity within embryos.
Increased oxidative activity and REDOX changes at the time of fertilization have been …

A review of the promises and pitfalls of oocyte and embryo metabolomics

L Nel-Themaat, ZP Nagy - Placenta, 2011 - Elsevier
Embryo viability assessment is one of the most important and challenging tasks in IVF.
Evaluation of embryo quality is critical when selecting the best embryo (s) to transfer or …

The role of oxygen in ruminant preimplantation embryo development and metabolism

AJ Harvey - Animal reproduction science, 2007 - Elsevier
The long-term effects of in vitro embryo culture on animal health are presently unknown,
however, current knowledge directs investigations toward understanding the mechanisms …

Application of extracellular flux analysis for determining mitochondrial function in mammalian oocytes and early embryos

B Muller, N Lewis, T Adeniyi, HJ Leese, DR Brison… - Scientific Reports, 2019 - nature.com
Mitochondria provide the major source of ATP for mammalian oocyte maturation and early
embryo development. Oxygen Consumption Rate (OCR) is an established measure of …

Dissecting flux balances to measure energetic costs in cell biology: Techniques and challenges

E Arunachalam, W Ireland, X Yang… - Annual Review of …, 2023 - annualreviews.org
Life is a nonequilibrium phenomenon: Metabolism provides a continuous supply of energy
that drives nearly all cellular processes. However, very little is known about how much …