Selenium (Se) is a micronutrient essential for life. Dietary intake of Se within the
physiological range is critical for human health and reproductive functions. Selenium levels …

Cancer remains an elusive, highly complex disease and a global burden. Constant change
by acquired mutations and metabolic reprogramming contribute to the high inter-and …

Thyroid diseases, including neoplasms, autoimmune diseases and thyroid dysfunctions, are
becoming a serious social problem with rapidly increasing prevalence. The latter is …

Simple Summary Glutathione peroxidase 1 (GPX1), as one of the most important antioxidant
enzymes, maintains cellular redox balance by regulating reactive oxygen species levels. In …

Thyroid cancer (TC) is the most common endocrine malignancy worldwide and its incidence
has increased dramatically in recent years. In parallel, the prevalence of overweight and …

Selenium, a non-metallic element, is a micronutrient essential for the biosynthesis of
selenoproteins containing selenocysteine. In adults, the thyroid contains the highest amount …

Differentiated thyroid cancers are more frequent in women than in men. These different
frequencies may depend on differences in patient's behavior and in thyroid investigations …

Selenium is an essential mineral element with important biological functions for the whole
body through incorporation into selenoproteins. This element is highly concentrated in the …

At physiological concentrations, reactive oxygen species (ROS), including superoxide
anions and H 2 O 2, are considered as second messengers that play key roles in cellular …

Background Glutathione peroxidases (GPXs) are an enzyme family with peroxidase activity.
Abnormal GPX expression is associated with carcinogenesis. However, the potential role of …