Recent advances in the development of non-PIKKs targeting small molecule inhibitors of DNA double-strand break repair
JM Kelm, A Samarbakhsh, A Pillai… - Frontiers in …, 2022 - frontiersin.org
The vast majority of cancer patients receive DNA-damaging drugs or ionizing radiation (IR)
during their course of treatment, yet the efficacy of these therapies is tempered by DNA …
during their course of treatment, yet the efficacy of these therapies is tempered by DNA …
Making connections: integrative signaling mechanisms coordinate DNA break repair in chromatin
DNA double-strand breaks (DSBs) are hazardous to genome integrity and can promote
mutations and disease if not handled correctly. Cells respond to these dangers by engaging …
mutations and disease if not handled correctly. Cells respond to these dangers by engaging …
DNA‐dependent phase separation by human SSB2 (NABP1/OBFC2A) protein points to adaptations to eukaryotic genome repair processes
ZJ Kovács, GM Harami, J Pálinkás… - Protein …, 2024 - Wiley Online Library
Single‐stranded DNA binding proteins (SSBs) are ubiquitous across all domains of life and
play essential roles via stabilizing and protecting single‐stranded (ss) DNA as well as …
play essential roles via stabilizing and protecting single‐stranded (ss) DNA as well as …
Crystal Structure of DNA Replication Protein SsbA Complexed with the Anticancer Drug 5-Fluorouracil
HH Su, YH Huang, Y Lien, PC Yang… - International Journal of …, 2023 - mdpi.com
Single-stranded DNA-binding proteins (SSBs) play a crucial role in DNA metabolism by
binding and stabilizing single-stranded DNA (ssDNA) intermediates. Through their …
binding and stabilizing single-stranded DNA (ssDNA) intermediates. Through their …
The Inhibitory Effects and Cytotoxic Activities of the Stem Extract of Sarracenia purpurea against Melanoma Cells and the SsbA Protein
HW Liu, WY Chiang, YH Huang, CY Huang - Plants, 2022 - mdpi.com
The Staphylococcus aureus SsbA protein (SaSsbA) is a single-stranded DNA-binding
protein (SSB) that is categorically required for DNA replication and cell survival, and it is thus …
protein (SSB) that is categorically required for DNA replication and cell survival, and it is thus …
The effect of replication protein A inhibition and post-translational modification on ATR kinase signaling
The ATR kinase responds to elevated levels of single-stranded DNA (ssDNA) to activate the
G2/M checkpoint, regulate origin utilization, preserve fork stability, and allow DNA repair to …
G2/M checkpoint, regulate origin utilization, preserve fork stability, and allow DNA repair to …
Exploration of naphthoquinone analogs in targeting the TCF-DNA interaction to inhibit the Wnt/β-catenin signaling pathway
The Wnt/β-catenin signaling pathway plays extensive roles in cancer initiation, proliferation,
and development, and has been implicated in the regulation of stem cells in the intestinal …
and development, and has been implicated in the regulation of stem cells in the intestinal …
[PDF][PDF] Assessing the efficacy of a new oligonucleotide drug in triple negative breast cancer
J Garwood - 2023 - eprints.qut.edu.au
This project investigated the efficacy of a new RNA-based drug in the treatment of triple-
negative breast cancer. Triple-negative breast cancer is the most difficult subtype of breast …
negative breast cancer. Triple-negative breast cancer is the most difficult subtype of breast …
Roles of Replication Factor a Post-Translational Modifications in Coordinating the DNA Damage Checkpoint
WA Larson - 2022 - search.proquest.com
Abstract Replication Factor A (RFA) is an essential protein complex conserved from yeast to
humans, which is required for the replication and repair of cellular DNA. When DNA damage …
humans, which is required for the replication and repair of cellular DNA. When DNA damage …