[HTML][HTML] Combination therapy in combating cancer
RB Mokhtari, TS Homayouni, N Baluch… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Combination therapy, a treatment modality that combines two or more therapeutic agents, is
a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy …
a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy …
Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies
Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …
[HTML][HTML] Recent developments in targeting carbonic anhydrase IX for cancer therapeutics
PC McDonald, JY Winum, CT Supuran, S Dedhar - Oncotarget, 2012 - ncbi.nlm.nih.gov
Carbonic anhydrase IX (CAIX) is a hypoxia-inducible enzyme that is overexpressed by
cancer cells from many tumor types, and is a component of the pH regulatory system …
cancer cells from many tumor types, and is a component of the pH regulatory system …
pH control mechanisms of tumor survival and growth
SK Parks, J Chiche… - Journal of cellular …, 2011 - Wiley Online Library
A distinguishing phenotype of solid tumors is the presence of an alkaline cellular feature
despite the surrounding acidic microenvironment. This phenotypic characteristic of tumors …
despite the surrounding acidic microenvironment. This phenotypic characteristic of tumors …
Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery
CT Supuran - Expert opinion on drug discovery, 2020 - Taylor & Francis
Introduction The spacious active site cavity of the metalloenzyme carbonic anhydrase (CA,
EC 4.2. 1.1) shows a great versatility for a variety of binding modes for modulators of activity …
EC 4.2. 1.1) shows a great versatility for a variety of binding modes for modulators of activity …
Structural annotation of human carbonic anhydrases
M Aggarwal, CD Boone, B Kondeti… - Journal of enzyme …, 2013 - Taylor & Francis
Carbonic anhydrases (CAs, EC 4.2. 1.1) are a family of metalloenzymes that catalyze the
reversible interconversion of CO2 and HCO3−. Of the 15 isoforms of human (h) α-CA, 12 are …
reversible interconversion of CO2 and HCO3−. Of the 15 isoforms of human (h) α-CA, 12 are …
Anticancer carbonic anhydrase inhibitors: a patent and literature update 2018-2022
Introduction Cancer affects an increasing number of patients each year with an
unacceptable death toll worldwide. A new therapeutic approach to combat tumors consists …
unacceptable death toll worldwide. A new therapeutic approach to combat tumors consists …
[HTML][HTML] Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation
BACKGROUND AND PURPOSE: Carbonic anhydrase (CA) IX expression is increased upon
hypoxia and has been proposed as a therapeutic target since it has been associated with …
hypoxia and has been proposed as a therapeutic target since it has been associated with …
Intracellular pH imaging in cancer cells in vitro and tumors in vivo using the new genetically encoded sensor SypHer2
MV Shirmanova, IN Druzhkova, MM Lukina… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Abstract Background Measuring intracellular pH (pH i) in tumors is essential for the
monitoring of cancer progression and the response of cancer cells to various treatments …
monitoring of cancer progression and the response of cancer cells to various treatments …
Synthesis and anti-inflammatory activity of sulfonamides and carboxylates incorporating trimellitimides: dual cyclooxygenase/carbonic anhydrase inhibitory actions
Trimellitimides 6–21 were prepared and investigated in vivo for anti-inflammatory and
ulcerogenic effects and in vitro for cytotoxicity. They were subjected to in vitro …
ulcerogenic effects and in vitro for cytotoxicity. They were subjected to in vitro …