The development of hepatocellular carcinoma (HCC) is a multistep process associated with
changes in host gene expression, some of which correlate with the appearance and …

Chronic infection with hepatitis B virus is associated with a high incidence of liver diseases,
including hepatocellular carcinoma. Hepatitis-B-virus-encoded X antigen (HBxAg) …

We have reported previously that the hepatitis B virus oncoprotein, HBx, can bind to the C
terminus of p53 and inhibit several critical p53-mediated cellular processes, including DNA …

Liver diseases associated with chronic hepatitis B virus (HBV) infection, including
hepatocellular carcinoma, account for more than 1 million deaths annually worldwide. In …

Chronic infection with hepatitis B virus (HBV) is a major risk factor for the development of
hepatocellular carcinoma (HCC). The pathogenesis of HBV‐induced malignant …

Transactivation of cellular genes and functional inactivation of p53 by the hepatitis B virus
(HBV) X gene-encoded protein (HBx) are proposed as alternative mechanisms for induction …

The X gene is conserved among mammalian hepadnaviruses and the X protein, pX, is
essential for viral propagation at least in the woodchuck. During the last decade, efforts have …

Hepatocellular carcinoma (HCC) is linked etiologically to viruses (hepatitis B virus [HBV] and
hepatitis C virus [HCV]), chemical carcinogens (ie, aflatoxins), and other environmental and …

Abstract p53 as a key molecular node in the stress response pathway, including
inflammation. p53 is involved in several critical pathways including cell cycle arrest …

Hepatitis B virus (HBV) is an important etiologic agent of chronic hepatitis, cirrhosis, and
hepatocellular carcinoma (HCC). Although the mechanism whereby HBV causes HCC is not …